Rate of initial highly active anti-retroviral therapy regimen change and its predictors among adult HIV patients at University of Gondar Referral Hospital, Northwest Ethiopia: a retrospective follow up study

Table 4 Bivariate and multivariable Cox regression analysis for predictors of initial HAART regimen change among adult HIV positive patients at University of Gondar Referral Hospital, January 2010 to June, 2015 (n = 410)

Variable	Survival status		Crude HR (95 % CI)	Adjusted HR (95 % CI)
Variable	Event	Censored	Crude HR (95 % CI)	Adjusted HR (95 % CI)
Weight
<60 kg	56	262	1.00	1.00
≥60 kg	32	60	1.91 (1.24–2.95)	1.19 (0.70–2.03)
Baseline WHO stage
Stage I/II	23	155	1.00	1.00
Stage III	50	122	2.45 (1.49–4.01)	1.92 (1.12–3.31)*
Stage IV	15	43	1.945 (1.01–3.73)	0.55 (0.25–1.18)
TB on initial regimen
Yes	20	6	7.92 (4.76–13.16)	8.33 (4.47–15.53)*
No	68	316	1.00	1.00
Initial NRTI backbone
TDF/ABC	26	151	1.00	1.00
AZT/D4T	62	171	1.68 (1.06–2.65)	072 (0.40–1.28)
Initial NNRTI
NVP	60	161	1.84 (1.17–2.88)	1.74 (0.79–3.84)
EFV	28	161	1.00	1.00
Co-medication with ART other than CPT
Yes	32	52	2.68 (1.74–4.15)	2.54 (1.46–4.39)*
No	56	270	1.00	1.00
Side effect
Yes	63	9	18.93 (11.82–30.29)	25.27 (15.12–42)*
No	25	313	1.00	1.00

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