Risk factors for unstructured treatment interruptions and association with survival in low to middle income countries

Table 4 Unadjusted and adjusted models for predictors of mortality across 33 MSF sites providing ART care

Model outcome	Level	Mortality		Mortality with lost to follow-up as a competing risk
Predictor	Level	Adjusted hazard ratio (95 % CI)	p value	Adjusted hazard ratio (95 % CI)	p value
Treatment interruption		0.21 (0.18, 0.23)	<0.01	0.95 (0.89, 1.02)	0.18
WHO stage at ART initiation	1	Ref.		Ref.
	2	1.06 (0.81, 1.40)	0.67	1.06 (0.80, 1.40)	0.68
	3	2.41 (1.95, 2.98)	<0.01	2.50 (2.02, 3.09)	<0.01
	4	4.31 (3.48, 5.33)	<0.01	4.50 (3.64, 5.56)	<0.01
CD4 count at ART initiation (cells/μL)	<200	Ref.		Ref.
	200–350	0.55 (0.48, 0.64)	<0.01	0.54 (0.47, 0.62)	<0.01
	>350	0.41 (0.30, 0.55)	<0.01	0.40 (0.29, 0.53)	<0.01

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