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Table 2 Characteristics of patients who did or did not discontinue their ART regimen within the first 12 months

From: Trends and factors associated with modification or discontinuation of the initial antiretroviral regimen during the first year of treatment in the Turkish HIV-TR Cohort, 2011–2017

Characteristic Total = 3019 Discontinued = 351 Continued = 2668 P
N (%) N (%) N (%)
Gender .083
 Male 2605 (86.3) 292 (83.2) 2313 (86.7)  
 Female 414 (13.7) 59 (16.8) 355 (13.3)  
Age (years) .021
 ≤ 45 2240 (75.0) 244 (69.9) 1996 (75.7)  
 > 45 746 (25.0) 105 (30.1) 641 (24.3)  
Mode of transmission .598
 MSM/Bisexual 1038 (34.4) 115 (32.8) 923 (34.6)  
 Heterosexual 1683 (55.7) 198 (56.4) 1485 (55.7)  
 IDU 6 (0.2) 1 (0.3) 5 (0.2)  
 Other 62 (2.1) 11 (3.1) 51 (1.9)  
 Unknown 230 (7.6) 26 (7.4) 204 (7.6)  
Pretreatment CD4 cell count (cells/mm3) .011
 < 200 723 (25.6) 104 (31.4) 619 (24.8)  
 ≥ 200 2103 (74.4) 227 (68.6) 1876 (75.2)  
Pretreatment viral load (copies/mL) .213
 < 100,000 1262 (45.0) 135 (41.7) 1127 (45.4)  
 ≥ 100,000 1545 (55.0) 189 (58.3) 1356 (54.6)  
AIDS diagnosis .006
 Yes 793 (26.3) 114 (32.5) 679 (25.4)  
 No 2226 (73.7) 237 (67.5) 1989 (74.6)  
ART regimen type <.001
 InSTI 1135 (37.6) 63 (17.9) 1072 (40.2)  
 InSTI/PI 6 (0.2) 1 (0.3) 5 (0.2)  
 NNRTI 798 (26.4) 109 (31.1) 689 (25.8)  
 PI 1080 (35.8) 178 (50.7) 902 (33.8)  
Type of initial ART <.001
 EFV/TDF/FTC 750 (24.8) 101 (28.8) 649 (24.3)  
 LPV/r/TDF/FTC 743 (24.6) 121 (34.5) 622 (23.3)  
 EVG/c/TDF/FTC 680 (22.5) 39 (11.1) 641 (24.0)  
 DTG/TDF/FTC 351 (11.6) 10 (2.8) 341 (12.8)  
 DRV/r/TDF/FTC 276 (9.1) 34 (9.7) 242 (9.1)  
 RAL/TDF/FTC 65 (2.2) 12 (3.4) 53 (2.0)  
 LPV/r/ZDV/3TC 53 (1.8) 21 (6.0) 32 (1.2)  
 EFV/ZDV/3TC 39 (1.3) 7 (2.0) 32 (1.2)  
 Other 62 (2.1) 6 (1.7) 56 (2.1)  
Year of ART initiation .031
 2011–2014 1495 (49.5) 193 (55.0) 1302 (48.8)  
 2015–2017 Feb 1524 (50.5) 158 (45.0) 1366 (51.2)  
  1. Missing values: 6% for CD4 cell counts, 7% for pretreatment viral load
  2. 3TC lamivudine, DRV darunavir, DTG dolutegravir, EFV efavirenz, EVG/c elvitegravir/cobicistat, FTC emtricitabine, InSTI integrase strand transfer inhibitor, IDU injection drug user, LPV lopinavir, MSM men who have sex with men, NNRTI non-nucleoside reverse transcriptase inhibitor, PI protease inhibitor, RAL raltegravir, r ritonavir, TDF tenofovir disoproxil fumarate, ZDV zidovudine
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