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2DR (N = 131)
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3DR (N = 132)
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Duration of ART [years]; median (IQR)
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5.1 (3.5–8.3)
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5.5 (3.4–8.4)
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Prior INSTI usea; n (%)
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9 (6.9)
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13 (9.8)
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History of ≥ 2 NRTI changes; n (%)
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22 (16.8)
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33 (25.0)
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History of ≥ 2 PI changes; n (%)
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17 (13.0)
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12 (9.1)
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History of ≥ 2 ART changes; n (%)
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27 (20.6)
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45 (34.1)
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Any major/minor RAM; n (%)
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49 (37.4)
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50 (37.9)
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NRTI RAMs; n (%)
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13 (9.9)
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12 (9.1)
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NNRTI RAMs; n (%)
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20 (15.3)
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18 (13.6)
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Any major/minor PI RAM; n (%)
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38 (29.0)
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41 (31.1)
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PI RAM, major (± minor); n (%)
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5 (3.8)
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4 (3.0)
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PI RAM, minor; n (%)
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33 (25.2)
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37 (28.0)
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- RAMs prior to baseline (in one or several cases): NRTI RAMs (M41I, M41L, A62V, D67N, T69N, T69S, K70R, V75I, F77L, Y115F, F116Y, M184I, Q151M, M184V, T215C, T215D, T215E, T215F, T215I, T215S, T215Y, K219E, K219Q); NNRTI RAMs (V90I, K101E, K101P, K101Q, K103N, K103R, V106I, V108I, E138A, E138K, V179D, V179E, V179I, V179T, Y181C, Y181V, Y188L, V189I, G190A, M230I); major PI RAMs (based on HIVdb version 8.9-1 as of 2019-10-25) [10]; D30N, V82F, V82S, V82T, N88S, L90M); and minor PI RAMs (L10I, L10M, L10V, K20I, K20M, K20R, K20T, L33F, L33V, E35D, M36I, M36L, R41K, K43T, I62V, L63P, H69K, A71I, A71L, A71T, A71V, T74S, V77I, N88D)
- aPrior INSTI use, n: raltegravir, 16; elvitegravir/cobicistat, 5; dolutegravir, 4; (n = 3 with prior use of two INSTIs)
