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  1. The pressing need to expand the biomedical HIV prevention evidence base during pregnancy is now increasingly recognized. Women’s views regarding participation in such trials and initiating PrEP while pregnant ...

    Authors: Kristen Sullivan, Tiwonge Mtande, Elana Jaffe, Nora Rosenberg, Chifundo Zimba, Irving Hoffman, Maggie Little, Ruth Faden and Anne Drapkin Lyerly

    Citation: AIDS Research and Therapy 2020 17:27

    Content type: Research

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  2. The clinical and laboratory characteristics of AIDS-associated Talaromyces marneffei infection, a rare but a fatal mycosis disease of the central nervous system, remain unclear.

    Authors: Yu-Ye Li, Rong-Jing Dong, Samip Shrestha, Pratishtha Upadhyay, Hui-Qin Li, Yi-Qun Kuang, Xin-Ping Yang and Yun-Gui Zhang

    Citation: AIDS Research and Therapy 2020 17:26

    Content type: Case Report

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  3. Metabolic complications in human immunodeficiency virus (HIV)-infected individuals are common. Prediabetes represents a high risk for future diabetes development. This study aimed to determine the prevalence, ...

    Authors: Angsana Phuphuakrat, Hataikarn Nimitphong, Sirimon Reutrakul and Somnuek Sungkanuparph

    Citation: AIDS Research and Therapy 2020 17:25

    Content type: Research

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  4. To explore the use of illicit drugs by people living with HIV (PLHIV) taking antiretroviral therapy (ART) and their relationship with variables relevant to the management of HIV infection, such as knowledge an...

    Authors: María José Fuster-RuizdeApodaca, Vanessa Castro-Granell, Ana Laguía, Ángeles Jaén, Santiago Cenoz and María José Galindo

    Citation: AIDS Research and Therapy 2020 17:24

    Content type: Research

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  5. The anti-retroviral combination of abacavir/lamivudine plus rilpivirine (ABC/3TC/RPV) is not recommended by international guidelines as the first-line regimen. However, it is potent, well-tolerated, and afford...

    Authors: Sharlene Ho, Joshua Guoxian Wong, Oon Tek Ng, Cheng Chuan Lee, Yee Sin Leo, David Chien Boon Lye and Chen Seong Wong

    Citation: AIDS Research and Therapy 2020 17:23

    Content type: Research

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  6. Pre-treatment drug resistance (PDR) among antiretroviral drug-naïve people living with HIV (PLHIV) represents an important indicator for the risk of treatment failure and the spread of drug resistant HIV varia...

    Authors: F. Neuhann, A. de Forest, E. Heger, A. Nhlema, C. Scheller, R. Kaiser, H. M. Steffen, H. Tweya, G. Fätkenheuer and S. Phiri

    Citation: AIDS Research and Therapy 2020 17:22

    Content type: Research

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  7. People living with HIV are living longer, and can experience physical, mental and social health challenges associated with aging and multimorbidity. Rehabilitation is well positioned to address disability and ...

    Authors: Kelly K. O’Brien, Francisco Ibáñez-Carrasco, Patricia Solomon, Richard Harding, Darren Brown, Puja Ahluwalia, Soo Chan Carusone, Larry Baxter, Charles Emlet, Gayle Restall, Alan Casey, Amrita Ahluwalia, Adria Quigley, Alex R. Terpstra and Nkem Ononiwu

    Citation: AIDS Research and Therapy 2020 17:21

    Content type: Research

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  8. Perinatal HIV infection negatively impacts cognitive functioning of children, main domains affected are working memory, processing speed and executive function. Early ART, even when interrupted, improves neuro...

    Authors: Christelle Ackermann, Savvas Andronikou, Muhammad G. Saleh, Martin Kidd, Mark F. Cotton, Ernesta M. Meintjes and Barbara Laughton

    Citation: AIDS Research and Therapy 2020 17:20

    Content type: Research

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  9. Through universal “test and treat approach” (UTT) it is believed that HIV new infection and AIDS related death will be reduced at community level and through time HIV can be eliminated. With this assumption th...

    Authors: Tadele Girum, Fedila Yasin, Abebaw Wasie, Teha Shumbej, Fitsum Bekele and Bereket Zeleke

    Citation: AIDS Research and Therapy 2020 17:19

    Content type: Research

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  10. About 13 years since the introduction of antiretroviral therapy (ART) for children living with HIV (CLHIV) in Zambia, HIV/AIDS testing and treatment guidelines for children have evolved over the years with lim...

    Authors: Tendai Munthali, Charles Michelo, Paul Mee, Crispin Moyo, Andrew Kashoka, Liswaniso Liswaniso, Innocent Chiboma and Jim Todd

    Citation: AIDS Research and Therapy 2020 17:18

    Content type: Research

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  11. Data on the survival status of older adults on antiretroviral treatment (ART) are scarce in sub-Saharan Africa. The objective of this study was to determine the survival status of people aged 50 years and olde...

    Authors: Joseph Mugisha Okello, Stephen Nash, Paul Kowal, Nirmala Naidoo, Somnath Chatterji, Ties Boerma and Janet Seeley

    Citation: AIDS Research and Therapy 2020 17:17

    Content type: Research

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  12. People with HIV (PHIV) with limited access to health services often experience suboptimal antiretroviral therapy (ART) adherence. We investigated whether a daily text messaging intervention improves ART adhere...

    Authors: Elizabeth M. Sherman, Jianli Niu, Shara Elrod, Kevin A. Clauson, Fadi Alkhateeb and Paula Eckardt

    Citation: AIDS Research and Therapy 2020 17:16

    Content type: Research

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  13. Increased intestinal barrier permeability and subsequent gut microbial translocation are significant contributors to inflammatory non-AIDS comorbidities in people living with HIV (PLWH). Evidence in animal mod...

    Authors: Jing Ouyang, Stéphane Isnard, John Lin, Brandon Fombuena, Debashree Chatterjee, Tomas Raul Wiche Salinas, Delphine Planas, Amélie Cattin, Augustine Fert, Etiene Moreira Gabriel, Laurence Raymond Marchand, Yonglong Zhang, Malcolm Finkelman, Yaokai Chen, Daniel E. Kaufmann, Nicolas Cermakian…

    Citation: AIDS Research and Therapy 2020 17:15

    Content type: Short Report

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  14. The high rate of mortality among HIV-vertically infected adolescents might be favoured by HIV drug resistance (HIVDR) emergence, which calls for timeous actions in this underserved population. We thus sought t...

    Authors: Joseph Fokam, Armanda Nangmo, Carlson Wandum, Desire Takou, Maria Mercedes Santoro, Anne-Esther Njom Nlend, Francis Ndongo Ateba, Paul Koki Ndombo, Nelly Kamgaing, Cedric Kamta, Andre Essiane, Virginie Lambo, Charles Fokunang, Dora Mbanya, Vittorio Colizzi, Carlo-Federico Perno…

    Citation: AIDS Research and Therapy 2020 17:14

    Content type: Research

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  15. The objectives of this study were to investigate the relationships between polymorphisms at the interferon lambda (IFNL) locus and CD4+:CD8+ ratio normalisation in people living with HIV (PLWH) on effective antir...

    Authors: Inês T. Freitas, Willard Tinago, Hirofumi Sawa, Julie McAndrews, Brenda Doak, Charlotte Prior-Fuller, Gerard Sheehan, John S. Lambert, Eavan Muldoon, Aoife G. Cotter, William W. Hall, Patrick W. G. Mallon and Michael J. Carr

    Citation: AIDS Research and Therapy 2020 17:13

    Content type: Research

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  16. Once-daily, single-tablet regimens (STRs) have been associated with improved patient outcomes compared to multi-tablet regimens (MTRs). This study evaluated real world adherence and persistence of HIV antiretr...

    Authors: Joshua Cohen, Anne Beaubrun, Richa Bashyal, Ahong Huang, Jieni Li and Onur Baser

    Citation: AIDS Research and Therapy 2020 17:12

    Content type: Research

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  18. The gut microbiota is emerging as a prominent player in maintaining health through several metabolic and immune pathways. Dysregulation of gut microbiota composition, also known as dysbiosis, is involved in th...

    Authors: Jing Ouyang, Stéphane Isnard, John Lin, Brandon Fombuena, André Marette, Bertrand Routy, Yaokai Chen and Jean-Pierre Routy

    Citation: AIDS Research and Therapy 2020 17:10

    Content type: Review

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  19. The aim of this study was to assess trends in drug resistance and associated clinical and programmatic factors at a national level during the rapid scale up of ART.

    Authors: Pengtao Liu, Hui Xing, Lingjie Liao, Yi Feng, Xuebing Leng, Jing Wang, Wei Kan, Jing Yan, Yang Li, Zhongbao Zuo, Yinghui You, Yuhua Ruan and Yiming Shao

    Citation: AIDS Research and Therapy 2020 17:9

    Content type: Research

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  20. Antiretroviral adherence is essential to HIV treatment efficacy. Various self-reported measures are commonly used for assessing antiretroviral adherence. Limited data are available regarding the validity of th...

    Authors: Quan Zhang, Xiaoming Li, Shan Qiao, Zhiyong Shen and Yuejiao Zhou

    Citation: AIDS Research and Therapy 2020 17:8

    Content type: Research

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  21. Expanded access to combination antiretroviral therapy (cART) throughout sub-Saharan Africa over the last decade has remarkably improved the prognosis of persons living with HIV (PLWH). However, some PLWH exper...

    Authors: Ernest Ekong, Nicaise Ndembi, Prosper Okonkwo, Patrick Dakum, John Idoko, Bolanle Banigbe, James Okuma, Patricia Agaba, William Blattner, Clement Adebamowo and Manhattan Charurat

    Citation: AIDS Research and Therapy 2020 17:7

    Content type: Research

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  22. In resource-limited settings, multi-experienced HIV infected patients are often prescribed raltegravir for salvage therapy. Patients failing raltegravir-containing regimens require other drugs including other ...

    Authors: Aurelio Orta-Resendiz, Roberto A. Rodriguez-Diaz, Luis A. Angulo-Medina, Mario Hernandez-Flores and Luis E. Soto-Ramirez

    Citation: AIDS Research and Therapy 2020 17:6

    Content type: Research

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  23. Entry inhibitors, such as Maraviroc, hold promise as components of HIV treatment and/or pre-exposure prophylaxis in Africa. Maraviroc inhibits the interaction between HIV Envelope gp120 V3-loop and CCR5 corece...

    Authors: Nontokozo D. Matume, Denis M. Tebit and Pascal O. Bessong

    Citation: AIDS Research and Therapy 2020 17:5

    Content type: Review

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  24. For migrant female sex workers (FSWs) at the Sino-Vietnamese border, the impact of work time in their current location on the spread of HIV/AIDS is not clear.

    Authors: Yu Zhang, Bingyu Liang, Deping Liu, Guangwu Wei, Shide Mo, Aidan Nong, Chuanyi Ning, Yanyan Liao, Junjun Jiang, PeiJiang Pan, Yuan Yang, Ning Zang, Dinh Vanphu, Nguyen Van, Li Ye, Hao Liang…

    Citation: AIDS Research and Therapy 2020 17:4

    Content type: Research

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  25. Despite advances in the treatment quality of HIV throughout the world, several countries are still facing numerous obstacles in delivering HIV treatment at a sufficiently high quality, putting patients’ lives ...

    Authors: S. Jespersen, F. Månsson, J. Lindman, C. Wejse, C. Medina, Z. J. da Silva, DdS Te, P. Medstrand, J. Esbjörnsson and B. L. Hønge

    Citation: AIDS Research and Therapy 2020 17:3

    Content type: Review

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  26. Resistance to antiretroviral drugs is a major challenge among Human Immunodeficiency Virus (HIV) positive patients receiving antiretroviral therapy (ART). Mutations that arise as a result of this are diverse a...

    Authors: Alisen Ayitewala, Fred Kyeyune, Pamela Ainembabazi, Eva Nabulime, Charles Drago Kato and Immaculate Nankya

    Citation: AIDS Research and Therapy 2020 17:2

    Content type: Research

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  27. Dolutegravir (DTG)-based antiretroviral therapy (ART) is currently the first-line treatment for people living with HIV. Neuropsychiatric adverse events (NP-AEs) have been reported with DTG but neuropsychiatric...

    Authors: Phillip Chan, Orlanda Goh, Eugène Kroon, Donn Colby, Carlo Sacdalan, Suteeraporn Pinyakorn, Peeriya Prueksakaew, Peter Reiss, Jintanat Ananworanich, Victor Valcour, Serena Spudich and Robert Paul

    Citation: AIDS Research and Therapy 2020 17:1

    Content type: Research

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  28. Tenofovir disoproxil fumarate (TDF) is widely used in the management of HIV-infection, but has been associated with renal impairment in a small proportion of patients. Tenofovir alafenamide (TAF), a novel prod...

    Authors: Dane Turner, Douglas Drak, Catherine C. O’Connor, David J. Templeton and David M. Gracey

    Citation: AIDS Research and Therapy 2019 16:40

    Content type: Research

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  29. Several studies demonstrate a correlation between sub-therapeutic concentrations of antiretroviral drugs and virologic failure. We examined the sensitivity, specificity and predictive values of sub-therapeutic...

    Authors: Allan Buzibye, Joseph Musaazi, Amrei von Braun, Sarah Nanzigu, Christine Sekaggya-Wiltshire, Andrew Kambugu, Jan Fehr, Mohammed Lamorde, Ursula Gutteck, Daniel Muller, Stefanie Sowinski, Steven J. Reynolds and Barbara Castelnuovo

    Citation: AIDS Research and Therapy 2019 16:39

    Content type: Research

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  30. Prior HIV testing and awareness of HIV-positive status were assessed among HIV-positive adults at 20 clinics in Eswatini. Of 2196 HIV-positive adults, 1183 (53.8%) reported no prior HIV testing, and 1948 (88.7...

    Authors: Harriet Nuwagaba-Biribonwoha, Yingfeng Wu, Averie Baird Gachuhi, Margaret L. McNairy, Veli Madau, Mathew Lamb, Sikhathele Mazibuko, Zandile Mnisi, Sean Burke, Neena Philip, Ruben Sahabo and Wafaa M. El Sadr

    Citation: AIDS Research and Therapy 2019 16:38

    Content type: Short Report

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  31. Kidney transplantation is now a viable alternative to dialysis in HIV-positive patients who achieve good immunovirological control with the currently available antiretroviral therapy regimens. This systematic ...

    Authors: Xin Zheng, Lian Gong, Wenrui Xue, Song Zeng, Yue Xu, Yu Zhang and Xiaopeng Hu

    Citation: AIDS Research and Therapy 2019 16:37

    Content type: Research

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  32. After the launching of the « Test & Treat » strategy and the wider accessibility to viral load (VL), evaluating virological success (VS) would help in meeting the UNAIDS targets by 2020 in Cameroon.

    Authors: Joseph Fokam, Samuel Martin Sosso, Bouba Yagai, Serge Clotaire Billong, Rina Estelle Djubgang Mbadie, Rachel Kamgaing Simo, Serge Valery Edimo, Alex Durand Nka, Aline Tiga Ayissi, Junie Flore Yimga, Désiré Takou, Sylvie Moudourou, Marinette Ngo Nemb, Jean-Bosco Nfetam Elat, Maria-Mercedes Santoro, Carlo-Federico Perno…

    Citation: AIDS Research and Therapy 2019 16:36

    Content type: Research

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  33. Against the current global trends, in the former Soviet Union (FSU) countries HIV prevalence is on the rise. Visa-free movement across borders has facilitated migrant-associated HIV transmission within this re...

    Authors: Aidana Amangaldiyeva, Salima Davlidova, Bauyrzhan Baiserkin, Natalya Dzissyuk, Jack DeHovitz and Syed Ali

    Citation: AIDS Research and Therapy 2019 16:35

    Content type: Review

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  34. To evaluate clinical outcomes after either immediate or deferred initiation of antiretroviral therapy in HIV-1-infected patients, presenting late with pneumocystis pneumonia (PCP) or toxoplasma encephalitis (TE).

    Authors: Guido Schäfer, Christian Hoffmann, Keikawus Arasteh, Dirk Schürmann, Christoph Stephan, Björn Jensen, Matthias Stoll, Johannes R. Bogner, Gerd Faetkenheuer, Jürgen Rockstroh, Hartwig Klinker, Georg Härter, Albrecht Stöhr, Olaf Degen, Eric Freiwald, Anja Hüfner…

    Citation: AIDS Research and Therapy 2019 16:34

    Content type: Research

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  35. We previously reported that four doses or four double doses of hepatitis B vaccination regimens could not significantly increase a response rate compared with standard doses. However, the antibody levels were ...

    Authors: Romanee Chaiwarith, Jutarat Praparattanapan, Wilai Kotarathititum, Jiraprapa Wipasa, Kanokporn Chaiklang and Khuanchai Supparatpinyo

    Citation: AIDS Research and Therapy 2019 16:33

    Content type: Short Report

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  36. Suboptimal adherence to HIV antiretroviral therapy (ART) and concomitant lack of viral control can have severe consequences for health and onward transmission among persons living with HIV. Little is known abo...

    Authors: James M. McMahon, Amy Braksmajer, Chen Zhang, Natalie Leblanc, Michael Chen, Angela Aidala and Janie Simmons

    Citation: AIDS Research and Therapy 2019 16:32

    Content type: Research

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  38. Expanded access to antiretroviral therapy (ART) leads to improved HIV/AIDS treatment outcomes in Nigeria, however, increasing rates of loss to follow-up among those on ART is threatening optimal standard achie...

    Authors: Ahmad Aliyu, Babatunde Adelekan, Nifarta Andrew, Eunice Ekong, Stephen Dapiap, Fati Murtala-Ibrahim, Iboro Nta, Nicaise Ndembi, Charles Mensah and Patrick Dakum

    Citation: AIDS Research and Therapy 2019 16:30

    Content type: Research

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  39. As antiretroviral therapy (ART) programs expand access, there is an increase in burden to a healthcare system. These results are reduced provider-patient contact time and poor programmatic and patient outcomes...

    Authors: Ahmad Aliyu, Samer El-Kamary, Jessica Brown, Bruce Agins, Nicaise Ndembi, Gambo Aliyu, Jibreel Jumare, Babatunde Adelekan, Patrick Dakum, Alash’le Abimiku and Manhattan Charurat

    Citation: AIDS Research and Therapy 2019 16:29

    Content type: Review

    Published on:

  40. Limited data are available regarding correlates of regular sexually transmitted infections (STIs) and HIV screening among female sex workers (FSW) in Sub-Saharan Africa. In this study, we aimed to assess the f...

    Authors: Richard Muhindo, Barbara Castelnuovo, Andrew Mujugira, Rosalind Parkes-Ratanshi, Nelson K. Sewankambo, Juliet Kiguli, Nazarius Mbona Tumwesigye and Edith Nakku-Joloba

    Citation: AIDS Research and Therapy 2019 16:28

    Content type: Research

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  41. A negative status following confirmatory Early Infant Diagnosis (EID) is the desired pediatric outcome of prevention of Mother to Child Transmission (PMTCT) programs. EID impacts epidemic control by confirming...

    Authors: Patrick Dakum, Monday Tola, Nta Iboro, Chukwuemeka A. Okolo, Olachi Anuforom, Christopher Chime, Sam Peters, Jibreel Jumare, Obinna Ogbanufe, Aliyu Ahmad and Nicaise Ndembi

    Citation: AIDS Research and Therapy 2019 16:27

    Content type: Research

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  42. According to the user instructions from the manufacturer of OraQuick HIV self-test (HIVST) kits, individuals whose kits show one red band should be considered to be HIV-negative, no matter how weak the band is...

    Authors: Rose Kisa, Joseph K. B. Matovu, Esther Buregyeya, William Musoke, Caroline J. Vrana-Diaz, Jeffrey E. Korte and Rhoda K. Wanyenze

    Citation: AIDS Research and Therapy 2019 16:26

    Content type: Short Report

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  43. Thailand has the highest prevalence of HIV among countries in Asia but has also been a pioneer in HIV prevention and treatment efforts in the region, reducing the incidence of new infections significantly over...

    Authors: Camilla Muccini, Trevor A. Crowell, Eugène Kroon, Carlo Sacdalan, Reshmie Ramautarsing, Pich Seekaew, Praphan Phanuphak, Jintanat Ananworanich, Donn J. Colby and Nittaya Phanuphak

    Citation: AIDS Research and Therapy 2019 16:25

    Content type: Review

    Published on:

  44. Two HIV virus types exist: HIV-1 is pandemic and aggressive, whereas HIV-2 is confined mainly to West Africa and less pathogenic. Despite the fact that it has been almost 40 years since the discovery of AIDS, ...

    Authors: Joakim Esbjörnsson, Marianne Jansson, Sanne Jespersen, Fredrik Månsson, Bo L. Hønge, Jacob Lindman, Candida Medina, Zacarias J. da Silva, Hans Norrgren, Patrik Medstrand, Sarah L. Rowland-Jones and Christian Wejse

    Citation: AIDS Research and Therapy 2019 16:24

    Content type: Review

    Published on:

  45. Darunavir/cobicistat/emtricitabine/tenofovir alafenamide (D/C/F/TAF) 800/150/200/10 mg is a once-daily, single-tablet regimen for treatment of HIV-1 infection. The efficacy/safety of switching to D/C/F/TAF ver...

    Authors: Gregory D. Huhn, Joseph J. Eron, Pierre-Marie Girard, Chloe Orkin, Jean-Michel Molina, Edwin DeJesus, Romana Petrovic, Donghan Luo, Erika Van Landuyt, Erkki Lathouwers, Richard E. Nettles, Kimberley Brown and Eric Y. Wong

    Citation: AIDS Research and Therapy 2019 16:23

    Content type: Research

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  46. There are approximately 72,000 people living with HIV/AIDS (PLHIV) in Peru. Non-adherence to antiretroviral therapy (ART) is the most important factor for therapeutic failure and the development of resistance....

    Authors: Juan M. Leyva-Moral, Blanca K. Loayza-Enriquez, Patrick A. Palmieri, Genesis M. Guevara-Vasquez, Ursula E. Elias-Bravo, Joan E. Edwards, María Feijoo-Cid, Lucy Y. Davila-Olano, Juan R. Rodriguez-Llanos and Franco E. Leon-Jimenez

    Citation: AIDS Research and Therapy 2019 16:22

    Content type: Research

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  47. Study aim was to evaluate the safety and durability of darunavir/cobicistat (DRV/c) in a real life setting.

    Authors: Lucia Taramasso, Elena Ricci, Antonio Cascio, Laura Valsecchi, Barbara Menzaghi, Nicola Squillace, Paolo Maggi, Giuseppe Vittorio De Socio, Chiara Dentone, Giordano Madeddu, Giovanni F. Pellicanò, Leonardo Calza, Goffredo Angioni, Paolo Bonfanti and Antonio Di Biagio

    Citation: AIDS Research and Therapy 2019 16:21

    Content type: Research

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  48. The South African public health system plays an important role in the delivery of HIV testing and treatment services. The health system is also an important conduit for targeted behaviour change communication ...

    Authors: Gavin George, Sean Beckett, Cherie Cawood, David Khanyile, Kaymarlin Govender and Ayesha B. M. Kharsany

    Citation: AIDS Research and Therapy 2019 16:20

    Content type: Research

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  49. Brazil is a low-and-middle income country (LMIC) that, despite having a large population and continental dimensions, has been able to successfully fight HIV/AIDS through a number of governmental and societal m...

    Authors: Adele S. Benzaken, Gerson F. M. Pereira, Lendel Costa, Amilcar Tanuri, André F. Santos and Marcelo A. Soares

    Citation: AIDS Research and Therapy 2019 16:19

    Content type: Review

    Published on:

  50. People living with HIV (PLHIV) constantly need to address social issues such as the cost of accessing care, stigma, and lack of social support which impacts on their level of adherence to clinic visits or anti...

    Authors: Babatunde Adelekan, Nifarta Andrew, Iboro Nta, Asabe Gomwalk, Nicaise Ndembi, Charles Mensah, Patrick Dakum and Ahmad Aliyu

    Citation: AIDS Research and Therapy 2019 16:17

    Content type: Research

    Published on:

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AIDS Research and Therapy

ISSN: 1742-6405

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